Project #3 Investigating the anti-scar effect of human orbital adipose tissue-derived mesenchymal stem cells

Approximately 10 million people worldwide suffer from corneal blindness. Corneal scars mediated by the development of myofibroblasts after traumatic injury, microbial infections, and some corneal surgeries are one of the most important causes of vision loss worldwide. For this reason, in cases where the cornea is damaged, it is important that it heals without scar tissue.

In recent years, mesenchymal stem cell (MSC) treatments have been increasing in corneal injuries. MSCs can be obtained from many different sources such as adipose tissue, bone marrow, Wharton gel, peripheral blood. The presence of adult stem cells of mesenchymal-derived in the cornea is known by studies. With their ability to differentiate into different cells and their specific immunological properties, they are among the promising cell therapy methods for tissue regeneration.

Recently, mesenchymal stem cells (MSCs) have attracted attention for their potential use in promoting scar-free healing of corneal stroma. In this context, we aim to investigate the ways in which human orbital adipose tissue-derived mesenchymal stem cells improve scar formation after corneal injuries.

This project is supported by Eskişehir Osmangazi University Research Project Funds.